Georgia Tech Coronavirus (Covid-19) Information

Metabolic Rules of Microbial Community Assembly

Alvaro Sanchez, Ph.D.
Department of Ecology & Evolutionary Biology
Yale University
 
ABSTRACT
Microbes form complex multi-species communities that play important roles across the biosphere. Metabolism is a major determinant of microbial community assembly, but a quantitative and predictive connection between nutrient composition and microbiome composition (and function) is lacking. Can we possibly predict which communities will form in a given, known environment?  We have addressed this question through a combination of metabolic modeling and quantitative experiments. Experimentally, we have followed a high-throughput "enrichment-culture" approach to cultivate large numbers of natural communities in synthetic environments with a defined nutrient composition. Our experiments indicate that community assembly in replicate environments follows simple and reproducible quantitative metabolic rules, despite substantial species-level variability. Explicit, quantitative metabolic models allow us to predict the assembly of communities in novel nutrients, suggesting that the relationship between nutrient composition and microbiome assembly can be explained from first principles.
 
Host: William Ratcliff, Ph.D.

Event Details

Date/Time:

  • Thursday, February 20, 2020
    10:55 am
Location: Room 1117-1118, Marcus Nanotechnology Building, 345 Ferst Dr. NW, Atlanta, GA 30332

Related Media

Click on image(s) to view larger version(s)

  • Alvaro Sanchez

Accessibility Information

Per accessibility compliance standards, this page may have links to files that would require the downloading of additional software:

  • Click here to download Microsoft Products.
  • Click here to download Adobe Reader.